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Embryology in the Quran: Difference between revisions
→The Formation of Bone and Clothing with Flesh: yet more useful science evidence, inc. for axial and point that 23:14 sounds like all the bones are present.
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In order to compare with science the Qur'anic statement that Allah makes 'ithaman (bones<ref name="LLitham"></ref>) and then clothes (fa-kasawna<ref name="LLkasawa"></ref>) the bones with lahman (flesh<ref name="LLlahm"></ref>), first we should see what science has discovered about the process of bone and muscle formation. Here is a brief description for both of them, without any detail on the relative timing of parallel processes. The section that follows afterwards contains numerous cited scientific sources stating the timing of these processes. | In order to compare with science the Qur'anic statement that Allah makes 'ithaman (bones<ref name="LLitham"></ref>) and then clothes (fa-kasawna<ref name="LLkasawa"></ref>) the bones with lahman (flesh<ref name="LLlahm"></ref>), first we should see what science has discovered about the process of bone and muscle formation. Here is a brief description for both of them, without any detail on the relative timing of parallel processes. The section that follows afterwards contains numerous cited scientific sources stating the timing of these processes. | ||
Mesoderm is the middle of the three layers of the early embryo. Some of the mesoderm cells form blocks called somites either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate | Mesoderm is the middle of the three layers of the early embryo. Some of the mesoderm cells form blocks called somites either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate into sclerotome and myotome, which form the cartilage models and become connective tissues (including muscles) of the axial skeleton (i.e. everything except the limbs, shoulders and pelvis). | ||
Another area of mesoderm (lateral plate mesoderm) proliferates especially quickly in certain positions to form the limb buds. There, mesenchyme cells condense into distinct masses within the limb buds. These mesenchyme cells differentiate into chondrocytes, which produce cartilage. Cartilage 'models' (or 'templates') of the future bones gradually form. Once the cartilage models have formed and while they are still growing, the cartilage is literally replaced with actual bone by osteoblasts (ossification) working outwards from centres of the cartilage models. Osteoclasts remove the remnants of the mineralized cartilage. Ossification also starts in the axial skeleton some time after it has begun in the limbs, except for the upper and lower jaw, which starts to ossify slightly earlier. | Another area of mesoderm (lateral plate mesoderm) proliferates especially quickly in certain positions to form the limb buds. There, mesenchyme cells condense into distinct masses within the limb buds. These mesenchyme cells differentiate into chondrocytes, which produce cartilage. Cartilage 'models' (or 'templates') of the future bones gradually form. Once the cartilage models have formed and while they are still growing, the cartilage is literally replaced with actual bone by osteoblasts (ossification) working outwards from centres of the cartilage models. Osteoclasts remove the remnants of the mineralized cartilage. Ossification also starts in the axial skeleton some time after it has begun in the limbs, except for the upper and lower jaw, which starts to ossify slightly earlier. | ||
Meanwhile, the process of muscle formation begins as soon as the limb buds appear. Myoblast cells migrate from somites to the limb buds. They aggregate into distinct masses, differentiating and fusing into muscle fibres, as the condensing mesenchyme starts to chondrify, and before the resulting cartilage models begin to ossify. | Meanwhile, the process of muscle formation begins as soon as the limb buds appear. Myoblast cells migrate from somites to populate the limb buds. They aggregate into distinct masses, differentiating and fusing into muscle fibres, as the condensing mesenchyme starts to chondrify, and before the resulting cartilage models begin to ossify. | ||
====The Timing of These Processes==== | ====The Timing of These Processes==== | ||
Here is the scientific evidence for the contemporaneous development of cartilage/bone and muscles | Here is the scientific evidence for the contemporaneous development of cartilage/bone and muscles. | ||
A very detailed account of musculo-skeletal development in the human limb by clinical-geneticist Robert Jan Galjaard can be read online.<ref>Galjaard, R.J.H 2003. [http://repub.eur.nl/res/pub/10474/030924_Galjaard,%20Robert-Jan%20Harmen.pdf Mapping Studies of Congenital Limb Anomalies]. Page 16 | A very detailed account of musculo-skeletal development in the human limb by clinical-geneticist Robert Jan Galjaard can be read online.<ref>Galjaard, R.J.H 2003. [http://repub.eur.nl/res/pub/10474/030924_Galjaard,%20Robert-Jan%20Harmen.pdf Mapping Studies of Congenital Limb Anomalies]. Page 16</ref> It details that muscle precursor cells migrate from the somites into the limb buds (ca. day 26), well before the condensing core of mesenchyme has started to chondrify into cartilage bone models in the upper part of the upper limb (ca. day 37), followed by the lower part (ca. day 41). The myoblasts have grouped into distinct masses by this stage and are differentiating into muscle fibres. The upper limbs later start to ossify (ca. day 54). | ||
Professor Peter Law confirms that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine. In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | Professor Peter Law confirms that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine. In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | ||
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Myoblasts have aggregated into ventral and dorsal masses in the upper limb by day 36 and the start of chondrification.<ref>Sivakumar, B. ''Congenital Hand Differences'' in Farhadieh, R. et. al. (ed.) Plastic and Reconstructive Surgery: Approaches and Techniques, Wiley, p.660</ref> | Myoblasts have aggregated into ventral and dorsal masses in the upper limb by day 36 and the start of chondrification.<ref>Sivakumar, B. ''Congenital Hand Differences'' in Farhadieh, R. et. al. (ed.) Plastic and Reconstructive Surgery: Approaches and Techniques, Wiley, p.660</ref> | ||
According to Rugh, Building blocks are present for 40 pairs of muscles, which are located from the base of the skull to the bottom of the spinal column by day 28<ref>Conception to Birth Roberts Rugh, Ph.D., Landrum B. Shettles, Ph.D., M.D. Harper & Row, (New York), 1971, p.35</ref>. Muscles appear in the pelvis day 31<ref>ibid. p.43</ref>. Movement of the muscles is being controlled by the nervous system by the 6th week <ref>ibid. p.34</ref>. All of the muscle blocks have appeared by day 36 after conception<ref>ibid. p.46</ref>. | A detailed account by Walker and Miranda, including useful diagrams, explains that after day 35, the premuscle regions of the limb containing myoblasts and fibroblasts become distinct and have started to fuse together to become myotubes (which form muscle fibres) by day 45. In the axial musculo-skeletal development, myotomes have migrated (these form axial muscle) and sclerotomes have started to condense into mesenchyme (which will form cartilage) in the 5th week. <ref>Walker, U. A., and Miranda, A. F. ''Muscle Metabolism in the Fetus and Neonate'' in Cowett, R. M. (ed.) Principles of Perinatal-Neonatal Metabolism, 2nd Edition, Volume 1, New York (Springer) 1998, pp.642-643</ref> | ||
According to Rugh, Building blocks are present for 40 pairs of muscles, which are located from the base of the skull to the bottom of the spinal column by day 28<ref>Conception to Birth Roberts Rugh, Ph.D., Landrum B. Shettles, Ph.D., M.D. Harper & Row, (New York), 1971, p.35</ref> (these are the myotomes of the somites). Muscles appear in the pelvis day 31<ref>ibid. p.43</ref>. Movement of the muscles is being controlled by the nervous system by the 6th week <ref>ibid. p.34</ref>. All of the muscle blocks have appeared by day 36 after conception<ref>ibid. p.46</ref>. | |||
In the 10th edition (2016) of the Developing Human, Keith Moore says that ossification of the long bones begins in the 8th week, starting with the upper limbs, followed by the lower limbs and pelvis<ref>Keith L. Moore, Ph..D., FIAC, FRSM T.V.N. Persaud, M.D., Ph.D., D.Sc., FRCPath W.B., The Developing Human: Clinically Oriented Embryology, , 10th Edition, Elseiver (Philadelphia), 2016, p. p.349</ref> (which concurs with Galjaard cited above). | In the 10th edition (2016) of the Developing Human, Keith Moore says that ossification of the long bones begins in the 8th week, starting with the upper limbs, followed by the lower limbs and pelvis<ref>Keith L. Moore, Ph..D., FIAC, FRSM T.V.N. Persaud, M.D., Ph.D., D.Sc., FRCPath W.B., The Developing Human: Clinically Oriented Embryology, , 10th Edition, Elseiver (Philadelphia), 2016, p. p.349</ref> (which concurs with Galjaard cited above). | ||
It is apparent from the above that muscle masses have started to form around the mesenchyme condensations around the same time as they begin to chondrify into cartilage models of the limb bones, and long before they have even begun to ossify. | It is apparent from the above that muscle masses have started to form around the mesenchyme condensations around the same time as they begin to chondrify into cartilage models of the limb bones, and long before they have even begun to ossify. Similarly, the process of muscle and cartilage formation begins at the same time for the axoskeleton. Muscles and cartilage, and bone that replaces it, continue their formation in parallel with each other. | ||
====Problems With The Qur'anic Description==== | ====Problems With The Qur'anic Description==== | ||
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Secondly, muscle and bone (or their precursors) develop contemporaneously, although the parallel processes start when muscle begins developing around condensations of mesenchyme that have only just begun to diffentiate into cartilage. Therefore, there is no scientific basis for the Qur'anic claim of a stage in which bone is later covered with flesh after its own formation. The prefix fa before khalaqna means "and then", indicating an uninterrupted sequence.<ref>فَ fa - [http://www.studyquran.org/LaneLexicon/Volume6/00000105.pdf Lane's Lexicon] Volume 6, page 2322</ref> | Secondly, muscle and bone (or their precursors) develop contemporaneously, although the parallel processes start when muscle begins developing around condensations of mesenchyme that have only just begun to diffentiate into cartilage. Therefore, there is no scientific basis for the Qur'anic claim of a stage in which bone is later covered with flesh after its own formation. The prefix fa before khalaqna means "and then", indicating an uninterrupted sequence.<ref>فَ fa - [http://www.studyquran.org/LaneLexicon/Volume6/00000105.pdf Lane's Lexicon] Volume 6, page 2322</ref> | ||
Even if we were to accept that the Qur'an was only referring to precursors of bone and not bone itself, even though it used the Arabic word for bone ('itham), and not cartilage (ghurdoof), the embryology is still wrong. Even if, with further and unjustifiable generosity, we suppose that the Qur'an means only the very beginning of the formation of the cartilage (chondrification) before they are in any sense complete shapes and the beginning of the formation of muscles, even this happens at the same stage (around day 41). Going back earlier still, it can even be pointed out that the precursors of muscles (myoblasts) and cartilage (mesenchyme) are present in the limb bud as soon as it arises. Of course, the natural reading of verse 23:14 is that the bones have some sort of meaningful shape, and can meaningfully be called bones. This is certainly not the case when the condensed mesenchyme | Even if we were to accept that the Qur'an was only referring to precursors of bone and not bone itself, even though it used the Arabic word for bone ('itham), and not cartilage (ghurdoof), the embryology is still wrong. Even if, with further and unjustifiable generosity, we suppose that the Qur'an means only the very beginning of the formation of the cartilage (chondrification) before they are in any sense complete shapes and the beginning of the formation of muscles, even this happens at the same stage (around day 41). Going back earlier still, it can even be pointed out that the precursors of muscles (myoblasts) and precursors to the cartilage (mesenchyme) are present in the limb bud as soon as it arises. | ||
Of course, the natural reading of verse 23:14 is that the bones have some sort of meaningful shape, and can meaningfully be called bones. This is certainly not the case when the condensed mesenchyme has merely started to chondrify. Furthermore, the natural reading of verse 23:14 is that all the bones have some meaningful presence worthy of the label 'bones' before Allah clothes them with flesh. | |||
We have more evidence that 23:14 refers to things already recognisable as bones being clothed with muscles or flesh elsewhere in the Qur'an. Verse 2:259 uses the same Arabic words as does 23:14 for 'bones', 'clothed' and 'flesh' to describe the resurrection of a donkey which had been dead for 100 years. The main embryology passages, such as verse 22:5 (see quote above) suggests that embryological development has similarities with resurrection. | We have more evidence that 23:14 refers to things already recognisable as bones being clothed with muscles or flesh elsewhere in the Qur'an. Verse 2:259 uses the same Arabic words as does 23:14 for 'bones', 'clothed' and 'flesh' to describe the resurrection of a donkey which had been dead for 100 years. The main embryology passages, such as verse 22:5 (see quote above) suggests that embryological development has similarities with resurrection. | ||