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Embryology in the Quran: Difference between revisions
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====Bone and Muscle Formation According to Medical Science==== | ====Bone and Muscle Formation According to Medical Science==== | ||
In order to compare with science the Quranic statement that Allah makes the lump of flesh bones ('ithaman<ref name="LLitham" />) and then clothes (fa-kasawna<ref name="LLkasawa" />) the bones with flesh (lahman<ref name="LLlahm" />), | In order to compare with science the Quranic statement that Allah makes the lump of flesh bones ('ithaman<ref name="LLitham" />) and then clothes (fa-kasawna<ref name="LLkasawa" />) the bones with flesh (lahman<ref name="LLlahm" />), it is necessary to see what science has discovered about the process of bone and muscle formation. Here is a brief description for both of them, without any detail on the relative timing of parallel processes. The section that follows afterwards contains numerous cited scientific sources stating the timing of these processes. Finally, a third section will compare this with the Quran. | ||
[[w:Mesoderm|Mesoderm]] is the middle of the three layers of the early embryo. Some of the mesoderm cells ([[w:Paraxial_mesoderm|paraxial mesoderm]]) form a series of blocks called [[w:Somite|somites]] either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate into sclerotome and myotome, which form the cartilage 'models' (or 'templates') and become connective tissues (including muscles) respectively of the future [[w:Axial_skeleton|axial skeleton]] (i.e. everything except the limbs, shoulders and pelvis). The myotome differentiates and migrates as the sclerotome is condensing into mesenchyme, which will produce cartilage. Each process occurs segmentally down the somites in a cranio-caudal sequence (head to tail). | [[w:Mesoderm|Mesoderm]] is the middle of the three layers of the early embryo. Some of the mesoderm cells ([[w:Paraxial_mesoderm|paraxial mesoderm]]) form a series of blocks called [[w:Somite|somites]] either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate into sclerotome and myotome, which form the cartilage 'models' (or 'templates') and become connective tissues (including muscles) respectively of the future [[w:Axial_skeleton|axial skeleton]] (i.e. everything except the limbs, shoulders and pelvis). The myotome differentiates and migrates as the sclerotome is condensing into mesenchyme, which will produce cartilage. Each process occurs segmentally down the somites in a cranio-caudal sequence (head to tail). | ||
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Professor Peter Law concurs that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., ''Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine.'' In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | Professor Peter Law concurs that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., ''Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine.'' In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | ||
A detailed account by Walker and Miranda | A detailed account by Walker and Miranda confirms that after day 35, the premuscle regions of the limb containing myoblasts and fibroblasts become distinct, by day 45 the myoblasts have started to fuse together to form the first myotubes (which continues for some weeks, forming the muscle fibres), and by day 50 the dorsal and ventral masses have been compartmentalized into the major anatomical muscles.<ref>Walker, U. A., and Miranda, A. F. ''Muscle Metabolism in the Fetus and Neonate'' in Cowett, R. M. (ed.) Principles of Perinatal-Neonatal Metabolism, 2nd Edition, Volume 1, New York: Springer, 1998, pp.642-643 [https://books.google.co.uk/books?id=eoy-BwAAQBAJ&pg=PA642#v=onepage&q&f=false Google Books preview][BR /]"The first multinucleated myotubes in limbs have been observed at day 45. By day 50, all bone rudiments have formed and the major anatomical muscles are compartmentalized into their definitive anatomical muscles by segregation from two premuscle masses that are located ventrally and dorsally from the prospective bone structures."</ref> | ||
In the 10th edition (2016) of the Developing Human, Keith Moore says that ossification of the long bones begins in the 8th week, starting with the upper limbs, followed by the lower limbs and pelvis<ref>Keith L. Moore, Ph..D., FIAC, FRSM T.V.N. Persaud, M.D., Ph.D., D.Sc., FRCPath W.B., The Developing Human: Clinically Oriented Embryology, 10th Edition, Philadelphia: Elseiver, 2016, p. p.349 [https://books.google.co.uk/books?id=pmKGBwAAQBAJ&pg=PA349#v=onepage&q&f=false Google Books preview]</ref> (which concurs with Galjaard cited above). | In the 10th edition (2016) of the Developing Human, Keith Moore says that ossification of the long bones begins in the 8th week, starting with the upper limbs, followed by the lower limbs and pelvis<ref>Keith L. Moore, Ph..D., FIAC, FRSM T.V.N. Persaud, M.D., Ph.D., D.Sc., FRCPath W.B., The Developing Human: Clinically Oriented Embryology, 10th Edition, Philadelphia: Elseiver, 2016, p. p.349 [https://books.google.co.uk/books?id=pmKGBwAAQBAJ&pg=PA349#v=onepage&q&f=false Google Books preview]</ref> (which concurs with Galjaard cited above). | ||
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====Problems With The Quranic Description==== | ====Problems With The Quranic Description==== | ||
Firstly, it is clear that actual bone formation (ossification) begins long after the process of muscle formation has begun to develop around its precursors. Since the myoblasts have already migrated and aggregated into distinct masses, nor can their subsequent fusing into myotubes and muscle fibres be described as "clothing" the bones (which in any case ossify in parallel). Therefore, there is no scientific basis for the Quranic claim of a stage in which bone is later | The prefix fa before kasawna (we clothed) means "and then", indicating an uninterrupted sequence.<ref>فَ fa - [http://www.studyquran.org/LaneLexicon/Volume6/00000105.pdf Lane's Lexicon] Volume 6, page 2322</ref> Further emphasising this, each stage is mentioned twice ("''nutfah''...''nutfah''...''alaqah'''...''alaqah''...''lump'', then we made the ''lump'' ''bones'', then we clothed the ''bones'' with flesh"). The whole verse conveys a sequential process. | ||
Firstly, it is clear from the above sections that actual bone formation (ossification) begins long after the process of muscle formation has begun to develop around its precursors. Since the myoblasts have already migrated and aggregated into distinct masses, nor can their subsequent fusing into myotubes and muscle fibres be described as "clothing" the bones (which in any case ossify and continue to grow in parallel with muscle development). Therefore, there is no scientific basis for the Quranic claim of a stage in which bone is later clothed with flesh after its own formation. | |||
It is sometimes claimed that the Quran was only referring to precursor cartilage models of the bones and not bone itself. However, this does not explain why the author of the Quran mentioned not cartilage (ghudhroof)<ref name="LLghudtroof">غضروف ghudhroof, alternatively spelt غرضوف ghurdoof - [http://www.studyquran.org/LaneLexicon/Volume6/00000032.pdf Lane's Lexicon] Volume 6, page 2248</ref>) but only bone ('itham)<ref name="LLitham"></ref>, which literally replaces the cartilage and starts to form well after muscle building blocks are in place. | It is sometimes claimed that the Quran was only referring to precursor cartilage models of the bones and not bone itself. However, this does not explain why the author of the Quran mentioned not cartilage (ghudhroof)<ref name="LLghudtroof">غضروف ghudhroof, alternatively spelt غرضوف ghurdoof - [http://www.studyquran.org/LaneLexicon/Volume6/00000032.pdf Lane's Lexicon] Volume 6, page 2248</ref>) but only bone ('itham)<ref name="LLitham"></ref>, which literally replaces the cartilage and starts to form well after muscle building blocks are in place. | ||
In any case its | In any case its description would still be wrong. The evidence set out above shows that muscle and bone (or their precursors) develop contemporaneously, although the parallel processes start when myoblasts migrate and form distinct masses around condensations of mesenchyme that have only just begun to differentiate into cartilage, as detailed above. | ||
For the same reason the Quran would still be wrong even to suppose, with a further stretch, that it means only the very beginning of the formation of the cartilage (chondrification) before they are in any sense complete shapes. Going back earlier still, it can even be pointed out that the precursors of muscles (myoblasts) and precursors to the cartilage (mesenchyme) are present in the limb bud as soon as it arises. | For the same reason the Quran would still be wrong even to suppose, with a further stretch, that it means only the very beginning of the formation of the cartilage (chondrification) before they are in any sense complete shapes. Going back earlier still, it can even be pointed out that the precursors of muscles (myoblasts) and precursors to the cartilage (mesenchyme) are present in the limb bud as soon as it arises. | ||
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However, the natural reading of verse 23:14 is that the bones have some sort of meaningful shape, and can meaningfully be called bones. This is certainly not the case when the condensed mesenchyme has merely started to produce cartilage. Furthermore, the natural reading of verse 23:14 is that all the bones have some meaningful presence worthy of the label 'bones' before Allah clothes them with flesh. As noted in the evidence above, fingers only start to even chondrify after muscle formation is already well underway in the upper part of the limbs. | However, the natural reading of verse 23:14 is that the bones have some sort of meaningful shape, and can meaningfully be called bones. This is certainly not the case when the condensed mesenchyme has merely started to produce cartilage. Furthermore, the natural reading of verse 23:14 is that all the bones have some meaningful presence worthy of the label 'bones' before Allah clothes them with flesh. As noted in the evidence above, fingers only start to even chondrify after muscle formation is already well underway in the upper part of the limbs. | ||
There is more evidence that 23:14 refers to things already recognizable as bones then being clothed with muscles or flesh elsewhere in the Quran. Verse 2:259 uses the same Arabic words as does 23:14 for 'bones', 'clothed' and 'flesh' to describe the resurrection of a donkey which had been dead for 100 years.<ref>[...]and look at your ass; and that We may make you a sign to men, and look at the bones, how We set them together, then clothed them with flesh[...] | |||
<BR>Transliteration: ''waonthur ila himarika walinajAAalaka ayatan lilnnasi waonthur ila alAAithami kayfa nunshizuha thumma naksooha lahman''<nowiki>}}</nowiki><br>{{Quran|2|259}}</ref> The main embryology passages such as verse 22:5 suggest that embryological development has similarities with resurrection.<ref name="22-5" /> | <BR>Transliteration: ''waonthur ila himarika walinajAAalaka ayatan lilnnasi waonthur ila alAAithami kayfa nunshizuha thumma naksooha lahman''<nowiki>}}</nowiki><br>{{Quran|2|259}}</ref> The main embryology passages such as verse 22:5 suggest that embryological development has similarities with resurrection.<ref name="22-5" /> | ||