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Embryology in the Quran: Difference between revisions
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====Leech==== | ====Leech==== | ||
Apologists who are fond of leech metaphors should consider that unlike a leech, which simply sucks blood from its host, the embryo circulates and exchanges blood and waste products with its mother.<ref>Barry Mitchell & Ram Sharma 2009. Embryology: An Illustrated Colour Text. Second Edition. Churchill Livingstone ElSevier. Page 10-11</ref> A leech has many characteristics such as size, behaviour, shape, color, appearance. Why would the author use 'alaqah intending such a metaphorical meaning when his listeners could not be expected to know in what respect the analogy applies? It is a typical Texan Sharpshooter fallacy<ref>{{cite web|quote= The Texas sharpshooter fallacy is an informal fallacy in which pieces of information that have no relationship to one another are called out for their similarities, and that similarity is used for claiming the existence of a pattern. This fallacy is the philosophical/rhetorical application of the multiple comparisons problem (in statistics) and apophenia (in cognitive psychology). It is related to the clustering illusion, which refers to the tendency in human cognition to interpret patterns where none actually exist. The name comes from a joke about a Texan who fires some shots at the side of a barn, then paints a target centered on the biggest cluster of hits and claims to be a sharpshooter.|url= http://en.wikipedia.org/wiki/Texas_sharpshooter_fallacy|title= Texas sharpshooter fallacy|publisher= Wikipedia|author= |date= accessed August 13, 2013|archiveurl= http://www.webcitation.org/query?url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FTexas_sharpshooter_fallacy&date=2013-08-13|deadurl=no}}</ref> of apologists to choose one characteristic - shape - then to an arbitrarily very limited degree find a similarity with an embryo, and draw any conclusions, particularly as the early embryo passes through a wide range of shapes and is itself a biological organism. Moreover, such apologetics have to conveniently ignore the embryo's yolk sac when depicting the embryo. | Apologists who are fond of leech metaphors should consider that unlike a leech, which simply sucks blood from its host, the embryo circulates and exchanges blood and waste products with its mother.<ref>Barry Mitchell & Ram Sharma 2009. Embryology: An Illustrated Colour Text. Second Edition. Churchill Livingstone ElSevier. Page 10-11</ref> A leech has many characteristics such as size, behaviour, shape, color, appearance. Why would the author use 'alaqah intending such a metaphorical meaning when his listeners could not be expected to know in what respect the analogy applies? It is a typical Texan Sharpshooter fallacy<ref>{{cite web|quote= The Texas sharpshooter fallacy is an informal fallacy in which pieces of information that have no relationship to one another are called out for their similarities, and that similarity is used for claiming the existence of a pattern. This fallacy is the philosophical/rhetorical application of the multiple comparisons problem (in statistics) and apophenia (in cognitive psychology). It is related to the clustering illusion, which refers to the tendency in human cognition to interpret patterns where none actually exist. The name comes from a joke about a Texan who fires some shots at the side of a barn, then paints a target centered on the biggest cluster of hits and claims to be a sharpshooter.|url= http://en.wikipedia.org/wiki/Texas_sharpshooter_fallacy|title= Texas sharpshooter fallacy|publisher= Wikipedia|author= |date= accessed August 13, 2013|archiveurl= http://www.webcitation.org/query?url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FTexas_sharpshooter_fallacy&date=2013-08-13|deadurl=no}}</ref> of apologists to choose one characteristic - shape - then to an arbitrarily very limited degree find a similarity with an embryo, and draw any conclusions, particularly as the early embryo passes through a wide range of shapes and is itself a biological organism. Moreover, such apologetics have to conveniently ignore the embryo's yolk sac, which gradually becomes incorporated into its developing gut, when depicting the embryo. | ||
====Congealed Blood==== | ====Congealed Blood==== | ||
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In order to compare with science the Qur'anic statement that Allah makes 'ithaman (bones<ref name="LLitham"></ref>) and then clothes (fa-kasawna<ref name="LLkasawa"></ref>) the bones with lahman (flesh<ref name="LLlahm"></ref>), first we should see what science has discovered about the process of bone and muscle formation. Here is a brief description for both of them, without any detail on the relative timing of parallel processes. The section that follows afterwards contains numerous cited scientific sources stating the timing of these processes. | In order to compare with science the Qur'anic statement that Allah makes 'ithaman (bones<ref name="LLitham"></ref>) and then clothes (fa-kasawna<ref name="LLkasawa"></ref>) the bones with lahman (flesh<ref name="LLlahm"></ref>), first we should see what science has discovered about the process of bone and muscle formation. Here is a brief description for both of them, without any detail on the relative timing of parallel processes. The section that follows afterwards contains numerous cited scientific sources stating the timing of these processes. | ||
Mesoderm is the middle of the three layers of the early embryo. Some of the mesoderm cells form blocks called somites either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate into sclerotome and myotome, which form the cartilage models and become connective tissues (including muscles) of the axial skeleton (i.e. everything except the limbs, shoulders and pelvis). | Mesoderm is the middle of the three layers of the early embryo. Some of the mesoderm cells form a series of blocks called somites either side of the neural tube (this tube will eventually form the spinal cord and brain). These somites will differentiate into sclerotome and myotome, which form the cartilage 'models' (or 'templates') and become connective tissues (including muscles) respectively of the future axial skeleton (i.e. everything except the limbs, shoulders and pelvis). The myotome differentiates and migrates as the sclerotome is condensing into mesenchyme, which will form cartilage. Each process occurs segmentally down the somites in a cranio-caudal sequence (head to tail). | ||
Another area of mesoderm (lateral plate mesoderm) proliferates especially quickly in certain positions to form the limb buds. There, mesenchyme cells condense into distinct masses within the limb buds. These mesenchyme cells differentiate into chondrocytes, which produce cartilage. Cartilage | Another area of mesoderm (lateral plate mesoderm) proliferates especially quickly in certain positions to form the limb buds. There, mesenchyme cells condense into distinct masses within the limb buds. These mesenchyme cells differentiate into chondrocytes, which produce cartilage. Cartilage models of the future limb bones gradually form (chondrification). Once the cartilage models have formed and while they are still growing, the cartilage is literally replaced with actual bone by osteoblasts (ossification) working outwards from centres of the cartilage models. Osteoclasts remove the remnants of the mineralized cartilage. Ossification also starts in the axial skeleton some time after it has begun in the limbs, except for the upper and lower jaw, which start to ossify slightly earlier. | ||
Meanwhile, the process of muscle formation begins as soon as the limb buds appear. Myoblast cells migrate from somites to populate the limb buds. They aggregate into distinct masses, differentiating and fusing into muscle fibres, as the condensing mesenchyme starts to chondrify, and before the resulting cartilage models begin to ossify. | Meanwhile, the process of limb muscle formation begins as soon as the limb buds appear. Myoblast cells migrate from somites to populate the limb buds. They aggregate into distinct masses, differentiating and fusing into muscle fibres, as the condensing mesenchyme starts to chondrify, and before the resulting cartilage models begin to ossify. | ||
====The Timing of These Processes==== | ====The Timing of These Processes==== | ||
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Here is the scientific evidence for the contemporaneous development of cartilage/bone and muscles. | Here is the scientific evidence for the contemporaneous development of cartilage/bone and muscles. | ||
A very detailed account of musculo-skeletal development in the human limb by clinical-geneticist Robert Jan Galjaard can be read online.<ref>Galjaard, R.J.H. [http://repub.eur.nl/res/pub/10474/030924_Galjaard,%20Robert-Jan%20Harmen.pdf Mapping Studies of Congenital Limb Anomalies]. Ablasserdam: Haveka, B.V., 2003, page 16 [http://www.webcitation.org/6lFwBQq9z webcitation archive link]</ref> It details that muscle precursor cells migrate from the somites into the limb buds (ca. day 26), well before the condensing core of mesenchyme has started to chondrify into cartilage bone models in the upper part of the upper limb (ca. day 37), followed by the lower part (ca. day 41). The myoblasts have grouped into distinct masses by this stage and are differentiating into muscle fibres. The upper limbs later start to ossify (ca. day 54). | A very detailed account of musculo-skeletal development in the human limb by clinical-geneticist Robert Jan Galjaard can be read online.<ref>Galjaard, R.J.H. [http://repub.eur.nl/res/pub/10474/030924_Galjaard,%20Robert-Jan%20Harmen.pdf Mapping Studies of Congenital Limb Anomalies]. Ablasserdam: Haveka, B.V., 2003, page 16 [http://www.webcitation.org/6lFwBQq9z webcitation archive link]</ref> It details that muscle precursor cells migrate from the somites into the limb buds (ca. day 26), well before the condensing core of mesenchyme has started to chondrify into cartilage bone models in the upper part of the upper limb (ca. day 37), followed by the lower part (ca. day 41). The myoblasts have grouped into distinct masses by this stage and are differentiating into muscle fibres. The upper limbs later start to ossify (ca. day 54). Chondrification of mesenchyme, the grouping of myogenic masses, and ossification all occur in a proximal-distal order (upper to lower part of each limb). | ||
Professor Peter Law confirms that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., ''Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine.'' In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | Professor Peter Law confirms that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., ''Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine.'' In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref> | ||
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Myoblasts have aggregated into ventral and dorsal masses in the upper limb by day 36 and the start of chondrification.<ref>Sivakumar, B. et. al. ''Congenital Hand Differences'' in Farhadieh, R. et. al. (ed.) Plastic and Reconstructive Surgery: Approaches and Techniques, Chichester: Wiley, 2015, p.660 [https://books.google.co.uk/books?id=tCq9BgAAQBAJ&pg=PA660#v=onepage&q&f=false Google books preview]</ref> | Myoblasts have aggregated into ventral and dorsal masses in the upper limb by day 36 and the start of chondrification.<ref>Sivakumar, B. et. al. ''Congenital Hand Differences'' in Farhadieh, R. et. al. (ed.) Plastic and Reconstructive Surgery: Approaches and Techniques, Chichester: Wiley, 2015, p.660 [https://books.google.co.uk/books?id=tCq9BgAAQBAJ&pg=PA660#v=onepage&q&f=false Google books preview]</ref> | ||
A detailed account by Walker and Miranda, including useful diagrams, explains that after day 35, the premuscle regions of the limb containing myoblasts and fibroblasts become distinct and have started to fuse together to become myotubes (which form muscle fibres) by day 45. In the axial musculo-skeletal development, myotomes have migrated (these form axial muscle) and sclerotomes have started to condense into mesenchyme (which will form cartilage) in the 5th week. <ref>Walker, U. A., and Miranda, A. F. ''Muscle Metabolism in the Fetus and Neonate'' in Cowett, R. M. (ed.) Principles of Perinatal-Neonatal Metabolism, 2nd Edition, Volume 1, New York: Springer, 1998, pp.642-643 [https://books.google.co.uk/books?id=eoy-BwAAQBAJ&pg=PA642#v=onepage&q&f=false Google Books preview]</ref> | A detailed account by Walker and Miranda, including useful diagrams, explains that after day 35, the premuscle regions of the limb containing myoblasts and fibroblasts become distinct and have started to fuse together to become myotubes (which form muscle fibres) by day 45. In the axial musculo-skeletal development, myotomes have migrated (these form axial muscle) and sclerotomes have started to condense into mesenchyme (which will form cartilage) in the 5th week.<ref>Walker, U. A., and Miranda, A. F. ''Muscle Metabolism in the Fetus and Neonate'' in Cowett, R. M. (ed.) Principles of Perinatal-Neonatal Metabolism, 2nd Edition, Volume 1, New York: Springer, 1998, pp.642-643 [https://books.google.co.uk/books?id=eoy-BwAAQBAJ&pg=PA642#v=onepage&q&f=false Google Books preview]</ref> | ||
According to Rugh, Building blocks are present for 40 pairs of muscles, which are located from the base of the skull to the bottom of the spinal column by day 28<ref>Conception to Birth Roberts Rugh, Ph.D., Landrum B. Shettles, Ph.D., M.D. Harper & Row, (New York), 1971, p.35</ref> (these are the myotomes of the somites). Muscles appear in the pelvis day 31<ref>ibid. p.43</ref>. Movement of the muscles is being controlled by the nervous system by the 6th week <ref>ibid. p.34</ref>. All of the muscle blocks have appeared by day 36 after conception<ref>ibid. p.46</ref>. | According to Rugh, Building blocks are present for 40 pairs of muscles, which are located from the base of the skull to the bottom of the spinal column by day 28<ref>Conception to Birth Roberts Rugh, Ph.D., Landrum B. Shettles, Ph.D., M.D. Harper & Row, (New York), 1971, p.35</ref> (these are the myotomes of the somites). Muscles appear in the pelvis day 31<ref>ibid. p.43</ref>. Movement of the muscles is being controlled by the nervous system by the 6th week <ref>ibid. p.34</ref>. All of the muscle blocks have appeared by day 36 after conception<ref>ibid. p.46</ref>. | ||